Mariné M, Espada R, Torrado J, Pastor FJ, Guarro J
Efficacy of a new formulation of amphotericin B in murine disseminated infections by Candida glabrata or Candida tropicalis. [JOURNAL ARTICLE]
Int J Antimicrob Agents 2009 Sep 2.
Amphotericin B microspheres (M-AMB) are a new, inexpensive formulation of amphotericin B. In this study, we tested the efficacy of this new formulation for treating murine disseminated infections by Candida glabrata or Candida tropicalis. M-AMB showed a similar efficacy to that of amphotericin B deoxycholate and liposomal amphotericin B in the treatment of both disseminated murine infections. Its low toxicity and inexpensive production costs make this formulation potentially attractive for the treatment of fungal infections.
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