| Title | Efficacy of a new formulation of amphotericin B in murine disseminated infections by Candida glabrata or Candida tropicalis. | | Author(s) | Mariné M, Espada R, Torrado J, Pastor FJ, Guarro J | | Institution | Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain. | | Source | Int J Antimicrob Agents 2009 Sep 2. | | Abstract | Amphotericin B microspheres (M-AMB) are a new, inexpensive formulation of amphotericin B. In this study, we tested the efficacy of this new formulation for treating murine disseminated infections by Candida glabrata or Candida tropicalis. M-AMB showed a similar efficacy to that of amphotericin B deoxycholate and liposomal amphotericin B in the treatment of both disseminated murine infections. Its low toxicity and inexpensive production costs make this formulation potentially attractive for the treatment of fungal infections. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19733036 |
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