Socha M, Sapin A, Damgé C, Maincent P
Influence of polymers ratio on insulin-loaded nanoparticles based on poly-epsilon-caprolactone and Eudragit((R)) RS for oral administration. [JOURNAL ARTICLE]
Drug Deliv 2009 Sep 8.
Nanoparticles loaded with two different commercial insulins (Actrapid((R)), Novorapid((R))) and based on different blends of a biodegradable polyester (poly-epsilon-caprolactone) and a polycationic non-biodegradable acrylic polymer (Eudragit((R)) RS) were characterized in vitro. The zeta potential was positive whenever Eudragit((R)) RS was part of the nanoparticles matrix. The encapsulation efficiency was ~ 96% except for Novorapid((R))-loaded particles of poly-epsilon-caprolactone (only 35%). In vitro release studies revealed a burst release from nanoparticles, which may be of interest for oral delivery. Novorapid-loaded nanoparticles were orally administered to diabetic rats and allowed the glycemia to be decreased when compared with free nanoparticles.
More from this journal |
