| Title | Influence of polymers ratio on insulin-loaded nanoparticles based on poly-epsilon-caprolactone and Eudragit((R)) RS for oral administration. | | Author(s) | Socha M, Sapin A, Damgé C, Maincent P | | Institution | Laboratory of Pharmaceutical Technology, School of Pharmacy, Nancy Cedex, France. | | Source | Drug Deliv 2009 Sep 8. | | Abstract | Nanoparticles loaded with two different commercial insulins (Actrapid((R)), Novorapid((R))) and based on different blends of a biodegradable polyester (poly-epsilon-caprolactone) and a polycationic non-biodegradable acrylic polymer (Eudragit((R)) RS) were characterized in vitro. The zeta potential was positive whenever Eudragit((R)) RS was part of the nanoparticles matrix. The encapsulation efficiency was ~ 96% except for Novorapid((R))-loaded particles of poly-epsilon-caprolactone (only 35%). In vitro release studies revealed a burst release from nanoparticles, which may be of interest for oral delivery. Novorapid-loaded nanoparticles were orally administered to diabetic rats and allowed the glycemia to be decreased when compared with free nanoparticles. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19737052 |
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