| Title | Capillary electrophoretic enantioseparation of m-nisoldipine using two different beta-cyclodextrins. | | Author(s) | Kong D, Yang W, Duan K, Cui Y, Xing S, Zhang X, Sheng X, Zhang L | | Institution | Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P.R. China. Fax: +86-311-86266419. | | Source | J Sep Sci 2009 Sep 10; 32(18):3178-3183. | | Abstract | The methods for the enantioseparation of m-nisoldipine, a new 1,4-dihydropyridine calcium ion antagonist, were developed. The elaborated methods of m-nisoldipine enantiomers separation were successfully performed using an anionic CD-sulfobutyl ether-beta-CD (SBE-beta-CD) or carboxymethyl-beta-CD as chiral selector. However, the results indicated that SBE-beta-CD was a better chiral selector for enantioseparation of the neutral m-nisoldipine. Furthermore, comparing the two SBE-beta-CDs, the derivative with a higher degree of substitution (DS) of 7.0 induced better enantioresolution than the one with low DS (4.0). In addition, possible chiral recognition mechanisms of dihydropyridines were discussed. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19746398 |
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