| Title | Sensitivity of fluorophore-quencher labeled microbubbles to externally applied static pressure. | | Author(s) | Yuan B | | Institution | Department of Biomedical Engineering, Catholic University of America, Washington, DC 20064, USA. yuan@cua.edu | | Source | Med Phys 2009 Aug; 36(8):3455-69. | | Abstract | A fluorophore-quencher (F-Q) labeled microbubble system is proposed as a sensor for measuring externally applied static pressure distribution in a tumor. To quantify the sensitivity of such an F-Q bubble system to the externally applied pressure, a model describing bubble response to the static pressure was derived. Additionally, a model connecting the fluorescence lifetime and bubble radius was developed for the basic F-Q bubble system. The sensitivity is quantified based on these models given typical parameters. Results show that it is possible to resolve as low as 1 mm Hg pressure variation when both the F-Q bubble system and the measurement system are optimized. Strategies for optimizing an F-Q bubble system are discussed. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19746779 |
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