| Title | Topical administration of cyclosporin A in a solid lipid nanoparticle formulation. | | Author(s) | Kim ST, Jang DJ, Kim JH, Park JY, Lim JS, Lee SY, Lee KM, Lim SJ, Kim CK | | Institution | Department of Biochemistry, Division of Brain Korea, College of Medicine, Korea University, Seoul, Korea. sungtae7@snu.ac.kr | | Source | Pharmazie 2009 Aug; 64(8):510-4. | | Abstract | Cyclosporin A (CsA)-loaded solid lipid nanoparticles (SLN) were developed for improved skin penetration. CsA-loaded SLN, prepared using a hot homogenization method, were nano-sized (about 73 nm) with a slightly negative surface charge (about -16 mV) and stable under physiological conditions regardless of CsA incorporation. In vitro permeation studies using murine skin mounted in the Franz-type vertical diffusion assembly revealed that the skin permeation efficiency of CsA-loaded SLN was 2-fold higher than that of CsA-oil mixture in viable skin. Furthermore, topically administered CsA-loaded SLN relieved symptoms of atopic dermatitis (AD) in an in vivo murine model of AD by decreasing the T helper (Th) 2 cell-related cytokines interleukin (IL)-4 and -5. These results suggest that SLN are effective drug carriers for topical delivery andthat CsA-loaded SLN can be therapeutically applied in allergy-related skin disorders. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19746839 |
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