Yang Z, Niu Y, Le Y, Ma X, Qiao C
Beta-lactamase inhibitory component from the roots of Fissistigma cavaleriei. [JOURNAL ARTICLE]
Phytomedicine 2009 Sep 9.
Therapeutic control of beta-lactamase-producing bacteria has been a major clinical problem. Development of drug combinations containing the beta-lactamase inhibitors has given clinicians a novel approach to controlling resistant organisms. In our search for beta-lactamase inhibitors from natural resources, we found that the methanol extract of the roots of Fissistigma cavaleriei showed an inhibitory effect on beta-lactamase. Bioassay-guided isolation of the extract yielded an active compound that was identified as salicylsalicylic acid by physical and spectroscopic methods. The compound showed inhibitory effects on beta-lactamase in a dose-dependent manner with IC(50) values of 71muM. Salicylsalicylic acid is not as potent as the original inhibitors such as clavulanic acid, but it may be developed to be potent beta-lactamase inhibitor by chemical modification.
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