The alternating power stroke of a 6-cylinder AAA protease chaperone engine. Molecular cell [Mol Cell] Journal article

In this issue of Molecular Cell, Augustin et al. (2009) describe the regulatory coupling of adjacent ATP subunits in the mitochondrial AAA protease ring along with the responsible molecular determinants and uncover its importance for membrane dislocation of substrates.

Molecular cell [Mol Cell]

Adenosine Triphosphatases
Adenosine Triphosphate
Allosteric Regulation
Amino Acid Motifs
Binding Sites
Catalytic Domain
Conserved Sequence
Energy Metabolism
Fungal Proteins
Humans
Hydrolysis
Kinetics
Metalloendopeptidases
Mitochondrial Membranes
Models, Molecular
Molecular Chaperones
Protein Subunits
Signal Transduction
Structure-Activity Relationship
Substrate Specificity
Yeasts