| Title | Influence of splitting on dissolution properties of metoprolol tablets. | | Author(s) | Vranić E, Uzunović A | | Institution | Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina. | | Source | Bosn J Basic Med Sci 2009 Aug; 9(3):245-9. | | Abstract | The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19754482 |
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