| Title | A novel strategy for managing clopidogrel-induced adverse skin reactions. | | Author(s) | McKenzie DB, Rao U, Hobson A, Levy T, Talwar S, Swallow R | | Institution | Dorset Heart Centre, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, East Dorset, United Kingdom. | | Source | EuroIntervention 2009 Sep; 5(4):470-4. | | Abstract | Aims: We conducted a prospective observational study using a course of steroids and antihistamines to treat a cohort of patients who developed skin reactions to clopidogrel, to assess whether dual antiplatelet therapy could be continued in an outpatient setting.Methods and results: This study included 2,701 patients who underwent percutaneous coronary intervention (PCI) at our centre over a 23 month period. Patients with skin reactions to clopidogrel were identified and then commenced on five days oral prednisolone (30mg/od) and chlorpheniramine (4 mg/tds) for seven days. A subsequent telephone survey was performed to evaluate a number of variables. The probability of the adverse reaction being secondary to clopidogrel was assessed using the Naranjo adverse drug reaction probability scale. Twenty (0.7%) patients were identified who developed adverse skin reactions to clopidogrel. There was complete resolution seen in the majority (89%) of patients within an average of 3.2 days following treatment. One patient had partial resolution, and one had no response to treatment, but both were able to continue clopidogrel.
Conclusions: We propose a novel, safe and effective way of managing clopidogrel-induced skin reactions using a short course of prednisolone and chlorpheniramine, without stopping or substituting clopidogrel. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19755336 |
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