Richer MJ, Horwitz MS
Preventing viral-induced type 1 diabetes. [Journal Article, Research Support, Non-U.S. Gov't]
Ann N Y Acad Sci 2009 Sep.:487-92.
The development of type 1 diabetes is, in part, dictated by the failure of regulatory T cells to maintain peripheral tolerance. As such, therapies aimed at correcting the declining function of regulatory T cells have been the subject of intense investigation. In this review, we discuss the potential of regulatory T cells to suppress autoreactive responses and prevent type 1 diabetes induced by viral infection while maintaining protective antiviral immunity.
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