Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance. The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] Journal article | | Title | Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance. | | Author(s) | Denzer C, Thiere D, Muche R, Koenig W, Mayer H, Kratzer W, Wabitsch M | | Institution | Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Hospital of Ulm, D-89075 Ulm, Germany. | | Source | J Clin Endocrinol Metab 2009 Oct; 94(10):3872-81. | | MeSH | Adolescent
Body Fat Distribution
Child
Cross-Sectional Studies
Fatty Liver
Female
Glucose Tolerance Test
Gonadal Steroid Hormones
Humans
Insulin Resistance
Intra-Abdominal Fat
Logistic Models
Male
Multivariate Analysis
Obesity
Prevalence
Sex Factors
Young Adult
| | Abstract | CONTEXT: Nonalcoholic fatty liver disease (NAFLD) is known to have a gender-dimorphic prevalence in obese children. Less information is available on predictive factors for NAFLD in obese youths.
OBJECTIVE: The aim of the study was to examine the prevalence pattern and to identify clinical and laboratory markers associated with the risk for NAFLD.
DESIGN: This was a cross-sectional study.
Setting: The study setting was a rehabilitation clinic. STUDY
PARTICIPANTS: A total of 532 obese subjects (291 girls) aged 8-19 yr participated in the study. MAIN
MEASUREMENTS: Steatosis hepatis and visceral fat mass were determined by ultrasound. Laboratory tests included serum lipids, adiponectin, high-sensitivity C-reactive protein, sex steroids, and an oral glucose tolerance test.
RESULTS: Prevalence of hepatic steatosis was significantly higher in boys (41.1%) than in girls (17.2%) and was highest in postpubertal boys (51.2%) and lowest in postpubertal girls (12.2%). Severity of steatosis was associated with increased visceral fat mass, insulin resistance, lower adiponectin levels, and higher blood pressure. Three factors were extracted from the panel of investigated parameters by principal component analysis. Logistic regression analysis revealed significant associations of simple steatosis with the "insulin resistance and visceral fat" factor and the "body fat distribution and inflammation" factor in both genders and additionally with the "steroid hormones" factor in girls. Risk for steatosis hepatis with concomitantly elevated ALT was associated only with "insulin resistance and visceral fat" in girls and with all three factors in boys.
CONCLUSION: Our results suggest significant associations of NAFLD with markers of visceral obesity and insulin resistance in both genders and gender-specific associations with parameters of body fat distribution and sex steroids. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19773396 |
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