| Title | Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. | | Author(s) | Crowley JJ, Fioravante D, Regehr WG | | Institution | Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. | | Source | Neuron 2009 Sep 24; 63(6):843-53. | | MeSH | Action Potentials
Animals
Animals, Newborn
Biophysics
Cell Line, Transformed
Cerebellum
Electric Stimulation
Excitatory Amino Acid Antagonists
GABA Antagonists
Humans
Inhibitory Postsynaptic Potentials
Neural Inhibition
Neurons
Nonlinear Dynamics
Patch-Clamp Techniques
Phosphinic Acids
Photic Stimulation
Piperazines
Propanolamines
Quinoxalines
Rats
Rats, Sprague-Dawley
Rhodopsin
Synapses
Time Factors
Transfection
| | Abstract | Throughout the brain, multiple interneuron types influence distinct aspects of synaptic processing. Interneuron diversity can thereby promote differential firing from neurons receiving common excitation. In contrast, Golgi cells are the sole interneurons regulating granule cell spiking evoked by mossy fibers, thereby gating inputs to the cerebellar cortex. Here, we examine how this single interneuron class modifies activity in its targets. We find that GABA(A)-mediated transmission at unitary Golgi cell --> granule cell synapses consists of varying contributions of fast synaptic currents and sustained inhibition. Fast IPSCs depress and slow IPSCs gradually build during high-frequency Golgi cell activity. Consequently, fast and slow inhibition differentially influence granule cell spike timing during persistent mossy fiber input. Furthermore, slow inhibition reduces the gain of the mossy fiber --> granule cell input-output curve, while fast inhibition increases the threshold. Thus, a lack of interneuron diversity need not prevent flexible inhibitory control of synaptic processing. | | Language | eng | | Pub Type(s) | In Vitro
Journal Article
Research Support, N.I.H., Extramural
| | PubMed ID | 19778512 |
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