| Title | Wistar Rat Skin As Surrogate For Human Skin In Nortriptyline Hydrochloride Patch Studies. | | Author(s) | Melero A, Lehr CM, Schäfer UF, Garrigues TM | | Institution | Department of Pharmacy and Pharmaceutics. University of Valencia. Av. VA Estellés, s/n, 46100-Burjassot (Valencia, Spain); Biopharmaceutics and Pharmaceutical Technology, Saarland University. Campus, 4-1, D-66123, Saarbrücken. | | Source | Int J Pharm 2009 Sep 22. | | Abstract | Six different matrices were prepared containing nortriptyline hydrochloride (NTH) with hydroxypropyl-methyl-cellulose as polymer. A mixture of transdermal enhancers was included as part of the vehicle. Diffusion studies were carried out through Wistar rat full thickness skin using Franz Cells. They were compared with previously determined Human Heat Separated Epidermis in order to test if this animal can be used as model for in vivo assays. A linear correlation was obtained between NTH diffusion coefficients through both skin types (r(2)=0.996). | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19781607 |
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