| Title | Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats. | | Author(s) | Velázquez C, Calzada F, Esquivel B, Barbosa E, Calzada S | | Institution | Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría; CORCE 2 degrees piso Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, CP 06725, México, D.F. | | Source | J Ethnopharmacol 2009 Sep 22. | | Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The flowers of Chiranthodendron pentadactylon Larreat. (Sterculiaceae) has been traditionally used as folk medicine in Mexico for the treatment of gastrointestinal disorders such as diarrhoea and dysentery. AIM OF THE STUDY: This study aimed to assess the antisecretory activity which supports the therapeutic use of C. pentadactylon and its flavonoids to treat diarrhoea.
MATERIALS AND METHODS: The methanol extract of C. pentadactylon, subsequent fractions, and flavonoids were evaluated on cholera toxin-induced intestinal secretion in rat jejunal loops model.
RESULTS: Three antisecretory flavonoids were isolated by bioassay-guided purification, namely, isoquercitrin 3, (+)-catechin 4 and (-)-epicatechin 5. Among them, epicatechin exhibited the most potent antisecretory activity with ID(50) of 8.3muM/kg. Its potency was close that of to loperamide (ID(50) 6.1muM/kg), drug used as control. Isoquercitrin (ID(50) 19.2muM/kg) and catechin (ID(50) 51.7muM/kg) showed moderate and weak activity, respectively.
CONCLUSION: The results of the present study lend some support to the anecdotal report for the traditional use of the flowers of C. pentadactylon in the control of dysentery. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19781621 |
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