Maddry JA, Ananthan S, Goldman RC, Hobrath JV, D Kwong C, Maddox C, Rasmussen L, Reynolds RC, Secrist JA, Sosa MI, White EL, Zhang W
Antituberculosis activity of the molecular libraries screening center network library. [JOURNAL ARTICLE]
Tuberculosis (Edinb) 2009 Sep 25.
There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.
More from this journal |
