Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] Journal article | | Title | Antituberculosis activity of the molecular libraries screening center network library. | | Author(s) | Maddry JA, Ananthan S, Goldman RC, Hobrath JV, D Kwong C, Maddox C, Rasmussen L, Reynolds RC, Secrist JA, Sosa MI, White EL, Zhang W | | Institution | Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA. | | Source | Tuberculosis (Edinb) 2009 Sep 25. | | Abstract | There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19783214 |
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