Wang WL, Liu PP, Zhang YP, Li J, Tao HW, Gu QQ, Zhu WM
2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17. [Journal Article]
Arch Pharm Res 2009 Sep; 32(9):1211-4.
A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC(50) value of 22 microM.
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