2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17. Archives of pharmacal research [Arch Pharm Res] Journal article | | Title | 2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17. | | Author(s) | Wang WL, Liu PP, Zhang YP, Li J, Tao HW, Gu QQ, Zhu WM | | Institution | Key Laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao, China. | | Source | Arch Pharm Res 2009 Sep; 32(9):1211-4. | | Abstract | A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC(50) value of 22 microM. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19784575 |
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