Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease. Pediatric blood & cancer [Pediatr Blood Cancer] Journal article | | Title | Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease. | | Author(s) | Gabrovsky A, Aderinto A, Spevak M, Vichinsky E, Resar LM | | Institution | Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland. | | Source | Pediatr Blood Cancer 2009 Sep 25. | | Abstract | Renal papillary necrosis in sickling hemoglobinopathies can lead to significant complications, including hemorrhage, obstruction, and infection. Despite its frequency, there are limited therapies for protracted hemorrhage. In the past, massive hemorrhage was managed with nephrectomy. Here, we report a patient with hemoglobin SC disease and prolonged, life-threatening hemorrhage from papillary necrosis successfully treated with oral, low-dose epsilon aminocaproic acid (EACA). Although further study is warranted, this case illustrates the need to consider EACA in the conservative management of renal papillary necrosis and significant hemorrhage in sickle cell hemoglobinopathies. Pediatr Blood Cancer (c) 2009 Wiley-Liss, Inc. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19785026 |
|
|
| |
Advertise on this site.
| | |
|
