Langerhans cell histiocytosis, a case of Letterer Siwe disease. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society [J La State Med Soc] Journal article | | Title | Langerhans cell histiocytosis, a case of Letterer Siwe disease. | | Author(s) | Pant C, Madonia P, Bahna SL, Bass PF, Jeroudi M | | Institution | Louisiana State University Health Sciences Center, Department of Medicine/Pediatrics, Shreveport, LA, USA. | | Source | J La State Med Soc 2009 Jul-Aug; 161(4):211-2. | | MeSH | Antineoplastic Agents
Child
Cladribine
Cytarabine
Drug Therapy, Combination
Histiocytosis, Langerhans-Cell
Humans
Male
Prednisone
Recurrence
Salvage Therapy
Skin
Vinblastine
| | Abstract | An 8-month-old male infant presented with a progressively worsening generalized rash of 5-6 months duration, fever, poor feeding, and abdominal distension. An initial laboratory workup revealed anemia, thrombocytopenia, and hepatosplenomegaly. The patient was started on i.v. antibiotics, and a working diagnosis of Langerhans cell histiocytosis was reached that was later confirmed with a skin biopsy. Subsequently, the patient received first-round chemotherapy with vinblastine and prednisone, on which he appeared to improve clinically; however, he soon relapsed. He then received combination salvage therapy with cladribine (2CdA) and cytarabine (Ara-C) for three cycles. The patient responded well to this regimen with resolution of his condition. The patient was then referred for a bone marrow transplant. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 19785312 |
|
|
| |
Advertise on this site.
| | |
|
