| Title | Long-term safety concerns with proton pump inhibitors. | | Author(s) | Ali T, Roberts DN, Tierney WM | | Institution | Department of Internal Medicine, University of Oklahoma, Oklahoma City, OK, USA. tauseef-ali@ouhsc.edu | | Source | Am J Med 2009 Oct; 122(10):896-903. | | MeSH | Anti-Ulcer Agents
Calcium
Case-Control Studies
Colonic Neoplasms
Deficiency Diseases
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Gastritis, Atrophic
Gastroesophageal Reflux
Humans
Incidence
Iron
Long-Term Care
Male
Monitoring, Physiologic
Osteoporosis
Proton Pump Inhibitors
Risk Assessment
Safety Management
Stomach Neoplasms
Time Factors
| | Abstract | Proton pump inhibitors (PPIs) are among the most widely prescribed medications worldwide. Their use has resulted in dramatic improvements in treatment of peptic ulcer disease and gastroesophageal reflux disease. Despite an acceptable safety profile, mounting data demonstrate concerns about the long-term use of PPIs. To provide a comprehensive review regarding the concerns of long-term PPI use, a literature search was performed to identify pertinent original and review articles. Despite study shortcomings, the collective body of information overwhelmingly suggests an increased risk of infectious complications and nutritional deficiencies. Data regarding any increased risk in gastric or colon malignancy are less convincing. PPIs have revolutionized the management and complications of acid-related disorders with a high margin of safety; however, with the data available, efforts to reduce the dosing of or discontinue the use of PPIs must be reassessed frequently. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 19786155 |
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