| Title | Paradoxical growth of C. dubliniensis does not preclude in vivo response to echinocandin therapy. | | Author(s) | Mariné M, Pastor FJ, Sahand IH, Pontón J, Quindós G, Guarro J | | Institution | Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain; Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Spain. | | Source | Antimicrob Agents Chemother 2009 Sep 28. | | Abstract | Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activity of anidulafungin, caspofungin and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were effective in a similar way for the treatment of experimental disseminated infections by C. dubliniensis strains showing or not abnormal growth in vitro. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19786599 |
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