| Title | Topical bevacizumab for corneal neovascularization after penetrating keratoplasty. | | Author(s) | Saxena S, Kishore P, Pandey S, Khattri M, Kumar D | | Institution | From the Department of Ophthalmology, CSM Medical University (Erstwhile King George's Medical University), Lucknow - India. | | Source | Eur J Ophthalmol 2009 Sep-Oct; 19(5):870-2. | | Abstract | Purpose. To evaluate the efficacy of topical bevacizumab for corneal neovascularization in graft rejection. Methods. A 55-year-old man presented with corneal neovascularization and graft rejection 6 months following penetrating keratoplasty (triple procedure) in the left eye. His best-corrected visual acuity (BCVA) was counting fingers at 1 meter. He was administered topical bevacizumab (4 mg/4 mL) in a dose of one drop twice a day for 15 days. No adjunct therapy was given during bevacizumab administration.
Results. After 1 month, his BCVA improved to 20/120. Corneal vascularization and stromal haze regressed. After 6 months, his BCVA improved to 20/60 with further regression in corneal vascularization and stromal haze. At 9-month follow-up, he maintained BCVA of 20/60.
Conclusions.Short-term topical bevacizumab therapy may potentially offer a safer and more effective alternative in treating graft rejection after penetrating keratoplasty. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19787612 |
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