| Title | The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story. | | Author(s) | Skaro AI, Jay CL, Baker TB, Wang E, Pasricha S, Lyuksemburg V, Martin JA, Feinglass JM, Preczewski LB, Abecassis MM | | Institution | Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. askaro@nmh.org | | Source | Surgery 2009 Oct; 146(4):543-52; discussion 552-3. | | MeSH | Adult
Aged
Bile Duct Diseases
Cholangiopancreatography, Endoscopic Retrograde
Death
Female
Graft Survival
Health Resources
Humans
Ischemia
Liver Transplantation
Male
Middle Aged
Tissue Donors
Tissue and Organ Procurement
Treatment Outcome
| | Abstract | BACKGROUND: Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers. We examined the mode, kinetics, and predictors of organ failure and resource utilization to more fully characterize outcomes after DCD LT.
METHODS: We reviewed the outcomes for 32 DCD and 237 donation after brain death (DBD) LT recipients at our institution.
RESULTS: Recipients of DCD livers had a 2.1 times greater risk of graft failure, a 2.5 times greater risk of relisting, and a 3.2 times greater risk of retransplantation compared with DBD recipients. DCD recipients had a 31.6% higher incidence of biliary complications and a 35.8% higher incidence of ischemic cholangiopathy. Ischemic cholangiography was primarily implicated in the higher risk of graft failure observed after DCD LT. DCD recipients with ischemic cholangiography experienced more frequent rehospitalizations, longer hospital stays, and required more invasive biliary procedures.
CONCLUSION: Related to higher complication rates, DCD recipients necessitated greater resource utilization. This more granular data should be considered in the decision to promote DCD LT. Modification of liver allocation policy is necessary to address those disadvantaged by a failing DCD graft. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
| | PubMed ID | 19789011 |
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