| Title | Trajectory approach to two-state kinetics of single particles on sculpted energy landscapes. | | Author(s) | Wu D, Ghosh K, Inamdar M, Lee HJ, Fraser S, Dill K, Phillips R | | Institution | California Institute of Technology, Pasadena, California, USA. | | Source | Phys Rev Lett 2009 Jul 31; 103(5):050603. | | Abstract | We study the trajectories of a single colloidal particle as it hops between two energy wells which are sculpted using optical traps. Whereas the dynamical behaviors of such systems are often treated by master-equation methods that focus on particles as actors, we analyze them instead using a trajectory-based variational method called maximum caliber (MaxCal). We show that the MaxCal strategy accurately predicts the full dynamics that we observe in the experiments: From the observed averages, it predicts second and third moments and covariances, with no free parameters. The covariances are the dynamical equivalents of Maxwell-like equilibrium reciprocal relations and Onsager-like dynamical relations. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19792475 |
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