Howley LW, di Maria M, Bailey A, Schaffer MS
Neonatal Long QT Syndrome Type 3 Predicted by Positive Lidocaine Challenge. [JOURNAL ARTICLE]
Pacing Clin Electrophysiol 2009 Sep 30.
A female infant presented with bradycardia and an electrocardiogram demonstrating 2:1 atrioventricular depolarization, a prolonged QT interval, and T wave alternans. After propranolol therapy was initiated, a lidocaine challenge was performed with progressive shortening of the QT interval. This positive lidocaine challenge prompted clinical suspicion of long QT syndrome type 3 (LQT3) and early initiation of mexiletine therapy. Subsequent genetic testing confirmed the infant's diagnosis of LQT3. (PACE 2009; 1-3).
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