Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science (New York, N.Y.) [Science] Journal article | | Title | Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. | | Author(s) | Kambris Z, Cook PE, Phuc HK, Sinkins SP | | Institution | Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. | | Source | Science 2009 Oct 2; 326(5949):134-6. | | MeSH | Aedes
Animals
Brugia pahangi
Elephantiasis, Filarial
Genes, Insect
Host-Parasite Interactions
Immunity, Innate
Insect Vectors
Longevity
Mosquito Control
Oligonucleotide Array Sequence Analysis
Reverse Transcriptase Polymerase Chain Reaction
Up-Regulation
Wolbachia
| | Abstract | Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19797660 |
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