| Title | Bacterial-modulated host immunity and stem cell activation for gut homeostasis. |
| Author(s) | Lee WJ |
| Institution | Division of Life and Pharmaceutical Science, Department of Life Science, Ewha Woman's University, and National Creative Research Initiative Center for Symbiosystem, Seoul 120-750, South Korea. lwj@ewha.ac.kr |
| Source | Genes Dev 2009 Oct 1; 23(19):2260-5. |
| MeSH | Animals
Bacteria
Cell Differentiation
Drosophila Proteins
Drosophila melanogaster
Homeostasis
Host-Pathogen Interactions
Intestines
Janus Kinases
NADPH Oxidase
Reactive Oxygen Species
Receptors, Notch
STAT Transcription Factors
Signal Transduction
Stem Cells
|
| Abstract | Although it is widely accepted that dynamic cross-talk between gut epithelia and microorganisms must occur to achieve gut homeostasis, the critical mechanisms by which gut-microbe interactions are regulated remain uncertain. In this issue of Genes & Development, Buchon and colleagues (pp. 2333-2344) revealed that the reaction of the gut to microorganisms is not restricted to activating immune systems, but extends to integrated responses essential for gut tissue homeostasis, including self-renewal and the differentiation of stem cells. Further investigation of the connection between immune response and stem cell regulation at the molecular level in the microbe-laden mucosal epithelia will accelerate our understanding of the regulatory mechanisms of gut homeostasis and of the pathogenesis of diseases such as chronic inflammatory diseases and colorectal cancers. |
| Language | eng |
| Pub Type(s) | Comment
Journal Article
Research Support, Non-U.S. Gov't
|
| PubMed ID | 19797765 |
