Effect of perphenazine enanthate on open-field test behaviour and stress-induced hyperthermia in domestic sheep. Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] Journal article | | Title | Effect of perphenazine enanthate on open-field test behaviour and stress-induced hyperthermia in domestic sheep. | | Author(s) | Pedernera-Romano C, Ruiz de la Torre José L, Badiella L, Manteca X | | Institution | Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain. | | Source | Pharmacol Biochem Behav 2009 Sep 30. | | Abstract | The open-field test (OFT) and stress-induced hyperthermia (SIH) have been used to measure individual differences in fear. The present study has been designed as a pharmacological validation of OFT and SIH as indicators of fear in sheep using perphenazine enanthate (PPZ), a long-acting neuroleptic. Twenty four ewes of two breeds, Lacaune and Ripollesa, were tested in an arena measuring 5mx2.5m. Treatment group received one dose of 1.5mg/kg of PPZ and control group received sterile sesame oil. All animals were tested for 10min and behaviours were recorded. Rectal temperature was measured at the beginning (T1) and at the end (T2) of the test. SIH was defined as the difference between T2 and T1. Sheep were tested on days 1, 2, 3, 4, 7 and 9 after PPZ injection. Variables were analysed using a mixed model. PPZ decreased bleats on days 2, 3, 4 and the SIH response on days 2 and 3. Breed differences were observed. Treated animals showed positive correlations between SIH and bleats; squares entered; attempts to escape and negative correlation between SIH and visits to the food bucket. Our results suggest that behaviour and SIH on the OFT are useful measures of fear in sheep. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19799930 |
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