Anxiety-like behavior induced by histaminergic agents can be prevented by cannabinoidergic WIN55,212-2 injected into the dorsal hippocampus in mice. Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] Journal article | | Title | Anxiety-like behavior induced by histaminergic agents can be prevented by cannabinoidergic WIN55,212-2 injected into the dorsal hippocampus in mice. | | Author(s) | Zarrindast MR, Nasehi M, Piri M, Bina P | | Institution | Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran; Institute for Cognitive Science Students, Tehran, Iran. | | Source | Pharmacol Biochem Behav 2009 Sep 30. | | Abstract | In the present study, we investigate the effects of the histaminergic system and cannabinoid receptor agents on anxiety-related behaviors and their interactions using the hole-board test on mice. Bilateral intra-CA1 administration of the CB1/CB2 receptor agonist, WIN55, 212-2 (0.1-0.5microg/mouse) did not modify exploratory behaviors in mice. On the other hand, intra-CA1 administration of CB1 receptor antagonist, AM251 (25 and 50 ng/mouse) or histamine, pyrilamine and ranitidine (5-10microg/mouse) decreased the amount of head-dipping and increased the first head-dip, suggesting an anxiogenic-like response. Furthermore, our present data indicated that the co-administration of WIN55, 212-2 (0.25microg/mouse) with histaminergic agents, decreased the anxiogenic-like response of an effective dose (5microg/mouse) of histamine and pyrilamine, but not that of ranitidine. In addition, the results demonstrated that co-administration of an ineffective dose of AM251 (15 ng/mouse) with histaminergic drugs did not alter the response induced by an ineffective dose (3.75microg/mouse) of either histamine or pyrilamine and ranitidine. In all experiments and doses, locomotor activity and other exploratory behaviors were not significantly changed. In conclusion, our results showed that there is a chance of partial interaction between the cannabinoidergic and the histaminergic systems of the dorsal hippocampus on anxiogenic/anxiolytic-like behaviors in hole-board test. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19800360 |
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