Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. The American journal of cardiology [Am J Cardiol] Journal article

Title	Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure.
Author(s)	Jorens PG, Van den Eynden GG
Institution	Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium. philippe.jorens@uza.be
Source	Am J Cardiol 2009 Oct 15; 104(8):1160-2.
MeSH	Arrhythmias, Cardiac Brain Edema Brain Injuries Child Diagnosis, Differential Fatal Outcome Heart Failure Hematoma, Epidural, Cranial Humans Hypnotics and Sedatives Infusions, Intravenous Male Propofol
Abstract	Propofol is a potent and widely used central-acting sedative drug. It has been implicated in the development of a usually fatal syndrome characterized by metabolic acidosis, rhabdomyolysis, ventricular arrhythmia, and Brugada-like cardiac rhythm disturbances, all leading to cardiac and renal failure. The investigators describe a 12-year-old male patient with a fatal case of this so-called propofol infusion syndrome. Postmortem investigation showed not only the well-known myocytolysis in skeletal and cardiac muscle but also not previously demonstrated widespread fat accumulation in the myocardium. In conclusion, this cardiac fat accumulation illustrates the proposed underlying pathophysiology of impaired (muscular) free fatty acid utilization.
Language	eng
Pub Type(s)	Case Reports Journal Article
PubMed ID	19801042

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