Prolonged manganese exposure induces severe deficits in lifespan, development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans. Journal of environmental sciences (China) [J Environ Sci (China)] Journal article

Title	Prolonged manganese exposure induces severe deficits in lifespan, development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans.
Author(s)	Xiao J, Rui Q, Guo Y, Chang X, Wang D
Institution	College of Life Sciences, Nanjing Normal University, Nanjing 210046, China. jing_xiao939@yahoo.com.cn
Source	J Environ Sci (China) 2009; 21(6):842-8.
Abstract	We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese (Mn) solution by monitoring the endpoints of lifespan, development, reproduction, and stress response. Our data suggest that acute exposure (6 h) to Mn did not cause severe defects of life span, development, and reproduction, similarly, no significant defect could be found in animals exposed to a low concentration of Mn (2.5 micromol/L) for 48 h. In contrast, prolonged exposure (48 h) to high Mn concentrations (75 and 200 micromol/L) resulted in significant defects of life span, development, and reproduction, as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals. Moreover, prolonged exposure (48 h) to high concentrations (75 and 200 micromol/L) of Mn decreased the expression levels of antioxidant genes of sod-1, sod-2, sod-3, and sod-4 compared to control. Therefore, prolonged exposure to high concentrations of Mn will induce the severe defects of life span, development, and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans.
Language	eng
Pub Type(s)	Journal Article Research Support, Non-U.S. Gov't
PubMed ID	19803092

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