Thromboprophylaxis in orthopedic surgery: how long is long enough? American journal of orthopedics (Belle Mead, N.J.) [Am J Orthop] Journal article | | Title | Thromboprophylaxis in orthopedic surgery: how long is long enough? | | Author(s) | Muntz J | | Institution | Baylor College of Medicine, Houston, Texas 77030, USA. jmuntz@tmhs.org | | Source | Am J Orthop 2009 Aug; 38(8):394-401. | | Abstract | Pharmacologic thromboprophylaxis with low-molecular-weight heparins, vitamin K antagonists, or fondaparinux is well tolerated and effective in preventing venous thromboembolism (VTE) in major orthopedic surgery but is often limited to in-hospital use. However, 45% to 80% of all symptomatic VTE events occur after hospital discharge. Extended-duration VTE prophylaxis for 28 to 35 days reduces risk for late VTE by up to 70%. In this article, I review the evidence supporting guideline recommendations regarding extended-duration prophylaxis after major orthopedic surgery and provide an overview of current and emerging literature regarding prevention of postoperative VTE in patients undergoing this surgery. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19809604 |
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