| Title | Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin. | | Author(s) | Riches PL, McRorie E, Fraser WD, Determann C, van't Hof R, Ralston SH | | Institution | Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom. | | Source | N Engl J Med 2009 Oct 8; 361(15):1459-65. | | MeSH | Adult
Autoantibodies
Autoimmune Diseases
Biological Markers
Bone Density
Bone Remodeling
Celiac Disease
Diet, Gluten-Free
Humans
Hypothyroidism
Immunoglobulin A
Male
Osteoporosis
Osteoprotegerin
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Transglutaminases
| | Abstract | Autoantibodies against osteoprotegerin, which block the inhibitory effect of osteoprotegerin on signaling by the receptor activator of nuclear factor (NF)-kappaB (RANK), were identified in a man with celiac disease who presented with severe osteoporosis and high bone turnover. The osteoporosis did not respond to the treatment of his celiac disease but was completely reversed by bisphosphonate therapy. Autoantibodies against osteoprotegerin were detected in three additional patients with celiac disease. Such autoantibodies may be associated with the development of high-turnover osteoporosis, but whether autoantibodies against osteoprotegerin commonly contribute to the pathogenesis of osteoporosis in patients with celiac disease remains to be determined. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19812402 |
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