Xu X, Graeff R, Xie Q, Gamble KL, Mori T, Johnson CH
Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop". [Comment, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.]
Science 2009 Oct 9; 326(5950):230; author reply 230.
Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR). In contrast, we found that there is no rhythm of cADPR levels nor are there any significant effects on the rhythm by cADPR overexpression, thus raising questions about the conclusions of Dodd et al.
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