KLF family members regulate intrinsic axon regeneration ability. Science (New York, N.Y.) [Science] Journal article | | Title | KLF family members regulate intrinsic axon regeneration ability. | | Author(s) | Moore DL, Blackmore MG, Hu Y, Kaestner KH, Bixby JL, Lemmon VP, Goldberg JL | | Institution | Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA. | | Source | Science 2009 Oct 9; 326(5950):298-301. | | MeSH | Animals
Axons
Cell Count
Cell Survival
Cells, Cultured
Down-Regulation
Gene Knockout Techniques
Growth Cones
Hippocampus
Kruppel-Like Transcription Factors
Mice
Nerve Crush
Nerve Regeneration
Neurites
Neurons
Optic Nerve Injuries
Rats
Retinal Ganglion Cells
Transcription, Genetic
Transfection
Up-Regulation
| | Abstract | Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons. RGCs lacking KLF4 showed increased axon growth both in vitro and after optic nerve injury in vivo. Related KLF family members suppressed or enhanced axon growth to differing extents, and several growth-suppressive KLFs were up-regulated postnatally, whereas growth-enhancing KLFs were down-regulated. Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 19815778 |
|
|
| |
Advertise on this site.
| | |
|
