| Title | Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. | | Author(s) | Mand S, Pfarr K, Sahoo PK, Satapathy AK, Specht S, Klarmann U, Debrah AY, Ravindran B, Hoerauf A | | Institution | Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany. mand@microbiology-bonn.de | | Source | Am J Trop Med Hyg 2009 Oct; 81(4):702-11. | | MeSH | Adolescent
Adult
Animals
Anthelmintics
Anti-Bacterial Agents
Diethylcarbamazine
Double-Blind Method
Doxycycline
Drug Administration Schedule
Elephantiasis, Filarial
Humans
Male
Middle Aged
Wuchereria bancrofti
Young Adult
| | Abstract | In a placebo controlled trial, the effects of 21- and 10-day doxycycline treatments (200 mg/day) followed by single dose diethylcarbamazine (administered 4 months post treatment) on depletion of Wolbachia endobacteria from Wuchereria bancrofti, filaricidal activity, and amerlioration of scrotal lymph vessel dilation were studied in 57 men from Orissa, India. The 21-day doxycycline course reduced Wolbachia in W. bancrofti by 94% before diethylcarbamazine administration. After 12 months, all patients with this treatment were amicrofilaremic and different from the 10-day doxycycline (42.9%) and placebo (37.5%) groups, and significantly fewer were positive for scrotal worm nests (6.7%) compared with 10-day doxycycline (60%) and placebo (66.7%). Average scrotal lymph vessel diameters were reduced from 0.7 cm pre-treatment to 0.02 cm in patients after 21 days of treatment, while no significant changes were seen in the other groups. This latter feature confirms the beneficial effects of doxycycline on lymphatic dilation and thus adds to the existing evidence that doxycycline, in addition to being macrofilaricidal, may be used to prevent or reverse lymphatic pathology. | | Language | eng | | Pub Type(s) | Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
| | PubMed ID | 19815891 |
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