| Title | Therapeutic vaccination and novel strategies to treat chronic HBV infection. | | Author(s) | Bertoletti A, Gehring A | | Institution | Viral Hepatitis Laboratory, Singapore Institute for Clinical Science, Agency of Science Technology and Research (A*STAR), 30 Medical Drive, 117609, Singapore, and Singapore Immunology Network, A*STAR, Singapore and Program on Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore. antonio_bertoletti@sics.a-star.edu.sg. | | Source | Expert Rev Gastroenterol Hepatol 2009 Oct; 3(5):561-569. | | Abstract | Therapeutic vaccination for the treatment of chronic hepatitis B has so far shown limited clinical efficacy. In this review, we argue that the principal cause of this failure is the profound defect of virus-specific T cells present in chronic hepatitis B patients and we discuss potential new ways to achieve an efficient restoration of virus-specific immunity in patients with chronic hepatitis B virus infection. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19817676 |
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