In vitro evaluation, biodistribution in rats of radiolabeled raloxifene. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] Journal article | | Title | In vitro evaluation, biodistribution in rats of radiolabeled raloxifene. | | Author(s) | Bayrak E, Lambrecht FY, Durkan K, Yilmaz O | | Institution | Ege University, Institute of Nuclear Science, Department of Nuclear Applications, Bornova, 35100 Izmir, Turkey. | | Source | Appl Radiat Isot 2009 Sep 19. | | Abstract | Raloxifene is a selective estrogen receptor modulator that produces both estrogen agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue. In the present study, raloxifene was labeled with I-131 by iodogen method and investigated for its radiopharmaceutical potential. Radiolabeling yield is 91+/-0.7%, as determined by radio thin layer chromatography (RTLC). Results of in vitro study indicated (131)I-raloxifene has high stability (4h) in serum. Biodistribution study was carried out with Albino wistar female rats. The result has shown that the radioiodinated raloxifene has higher uptake in uterus than breast and ovarian. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19819155 |
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