Acute antibody-mediated rejection after ABO-incompatible kidney transplantation treated successfully with antigen-specific immunoadsorption. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] Journal article | | Title | Acute antibody-mediated rejection after ABO-incompatible kidney transplantation treated successfully with antigen-specific immunoadsorption. | | Author(s) | Just SA, Marcussen N, Sprogøe U, Koefoed-Nielsen P, Bistrup C | | Institution | 1Department of Clinical Immunology. | | Source | Nephrol Dial Transplant 2009 Oct 9. | | Abstract | ABO-incompatible kidney transplantation is possible after pre-treatment with rituximab, intravenous immunoglobulin and basiliximab combined with tacrolimus, mycophenolate mofetil and prednisolone. We report on the first patient treated with this protocol who developed acute antibody-mediated rejection (Banff grade II with IgG deposits) caused by ABO antibodies (anti-B). Anti-rejection treatment with anti-B-specific immunoadsorption, intravenous immunoglobulin and methylprednisolone efficiently cleared deposited IgG from the kidney allograft and re-established normal kidney function. We suggest that ABO-incompatible kidney transplantation complicated by acute antibody-mediated rejection, caused by ABO antibodies, may successfully be treated with this regime. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19820002 |
|
|
| |
Advertise on this site.
| | |
|
