| Title | Defining the importance of daily glycemic control and implications for type 2 diabetes management. | | Author(s) | Bode BW | | Institution | Atlanta Diabetes Associates, Atlanta, GA 30309, USA. bbode001@aol.com | | Source | Postgrad Med 2009 Sep; 121(5):82-93. | | MeSH | Adamantane
Antigens, CD26
Blood Glucose Self-Monitoring
Circadian Rhythm
Cost of Illness
Diabetes Complications
Diabetes Mellitus, Type 2
Dipeptides
Disease Progression
Drug Therapy, Combination
Glycemic Index
Hemoglobin A, Glycosylated
Humans
Incretins
Pyrazines
Treatment Failure
Triazoles
| | Abstract | Glycemic control remains an elusive goal for most patients with type 2 diabetes. Questions concerning glucose targets that have emerged from recent outcomes studies further complicate glucose control strategies. Navigating through these challenges requires an understanding of the relationship between hyperglycemia, glycemic variability, and risk, as well as how to combine antidiabetic agents safely and effectively to minimize complications. Relevant data were selected from recently published major outcomes studies and peer-reviewed articles discussing glycemic variability, incretins, and dipeptidyl peptidase-4 inhibition. Incretin hormones play a premier role in maintaining normal glucose homeostasis. In type 2 diabetes, however, incretin functioning is impaired and glucose homeostasis is disturbed, contributing to hyperglycemia and both acute and chronic glucose fluctuations. Glycemic control efforts should involve quarterly glycated hemoglobin assessments, routine monitoring of daily blood glucose values, and combination therapy that targets both fasting and postprandial hyperglycemia. Dipeptidyl peptidase-4 inhibitors, which enhance endogenous incretin function, are well suited for combination with other agents to promote daily glycemic control without increasing the risk of hypoglycemia or weight gain. Results of recent outcomes studies suggest that a lifetime strategy for diabetes management might involve aggressive efforts to control glycemia daily and early in type 2 diabetes, with less stringent glucose targets and avoidance of hypoglycemia as patients acquire comorbidities, such as advanced cardiovascular disease. Dipeptidyl peptidase-4 inhibitors have the potential to play a vital role in diabetes management at all stages of the disease. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
Review
| | PubMed ID | 19820277 |
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