Serizawa I, Imai R, Kamada T, Tsuji H, Kishimoto R, Kandatsu S, Tsujii H, Tatezaki SI
Changes in Tumor Volume of Sacral Chordoma After Carbon Ion Radiotherapy. [JOURNAL ARTICLE]
J Comput Assist Tomogr 2009 September/October; 33(5):795-798.
OBJECTIVE:: We evaluated changes in tumor volume in cases of sacral chordoma after carbon ion radiotherapy.
METHODS:: Thirty-four patients with sacral chordoma underwent carbon ion radiotherapy between June 1996 and June 2003. We assessed 23 patients without previous surgery using T2-weighted magnetic resonance imaging. The tumor volume was calculated semiautomatically.
RESULTS:: Two cases showed local recurrence. The median interval of this examination was 46 months. At the end of the treatment, the tumor showed an enlargement larger than 10% of its volume in 13 of the 23 cases, no change in 4 cases, and regression in 6 cases. At the last examination, 20 cases showed a reduction in tumor volume, and the median ratio, determined as the tumor volume at the last examination divided by that before the treatment, was 0.36.
CONCLUSIONS:: An increase in tumor volume at the end of the treatment does not indicate the ineffectiveness of carbon ion radiotherapy.
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