Aldinucci D, Rapana' B, Olivo K, Lorenzon D, Gloghini A, Colombatti A, Carbone A
IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma. [JOURNAL ARTICLE]
Br J Haematol 2009 Oct 11.
Summary The effects of proliferative, apoptotic and anti-proliferative stimuli on interferon regulatory factor 4 (IRF4) expression by Reed-Sternberg (RS) cells were analysed using a panel of Hodgkin lymphoma (HL)-derived cell lines. IRF4 expressed by HL cells was consistently upregulated after CD40 engagement; IRF4 was downregulated by agonistic anti-CD95 antibodies in the FAS-sensitive HDLM-2 cells and after treatment with Adriamycin and Dacarbazine, two chemotherapic agents commonly used for HL treatment. These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology.
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