Polymyoclonus, laryngospasm, and cerebellar ataxia associated with adenocarcinoma and multiple neural cation channel autoantibodies. Archives of neurology [Arch Neurol] Journal article | | Title | Polymyoclonus, laryngospasm, and cerebellar ataxia associated with adenocarcinoma and multiple neural cation channel autoantibodies. | | Author(s) | Lim SY, Mason WP, Young NP, Chen R, Bower JH, McKeon A, Pittock SJ, Lang AE | | Institution | University of Malaya, Kuala Lumpur, Malaysia. | | Source | Arch Neurol 2009 Oct; 66(10):1285-7. | | MeSH | Adenocarcinoma
Aged
Autoantibodies
Brain Neoplasms
Calcium Channels, P-Type
Calcium Channels, Q-Type
Cerebellar Ataxia
Electromyography
Extremities
Female
Gastroesophageal Reflux
Humans
Immunization, Passive
Ion Channels
Laryngismus
Muscle, Skeletal
Myoclonus
Positron-Emission Tomography
Potassium Channels
Tomography, X-Ray Computed
| | Abstract | OBJECTIVE: To describe and provide audiovisual documentation of a syndrome of polymyoclonus, laryngospasm, and cerebellar ataxia associated with adenocarcinoma and multiple neural cation channel autoantibodies.
DESIGN: Case report with video.
SETTING: University hospitals. Patient A 69-year-old woman presented with subacute onset of whole-body tremulousness and laryngospasm attributed to gastroesophageal reflux.
RESULTS: Further evaluation revealed polymyoclonus, cerebellar ataxia, and laryngospasm suspicious of an underlying malignant neoplasm. Surface electromyography of multiple limb muscles confirmed the presence of polymyoclonus. The patient was seropositive for P/Q-type voltage-gated calcium channel antibody; subsequently, whole-body fluorine 18 fluorodeoxyglucose positron emission tomography and cervical lymph node biopsy revealed widespread metastatic adenocarcinoma. Follow-up serologic evaluation revealed calcium channel antibodies (P/Q type and N type) and potassium channel antibody.
CONCLUSIONS: We highlight the importance of recognizing polymyoclonus. To our knowledge, this is also the first description of a syndrome of polymyoclonus, laryngospasm, and ataxia associated with adenocarcinoma and these cation channel antibodies. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 19822786 |
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