Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. Behavioral neuroscience [Behav Neurosci] Journal article | | Title | Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. | | Author(s) | Ismail N, Girard-Bériault F, Nakanishi S, Pfaus JG | | Institution | Center for Studies in Behavioral Neurobiology. | | Source | Behav Neurosci 2009 Oct; 123(5):992-9. | | Abstract | Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats received saline, the opioid receptor antagonist naloxone, or the dopamine receptor antagonist flupenthixol prior to 10 conditioning trials in a pacing chamber with an almond-scented female. On the final test, all males were injected with saline and given access to 2 females, 1 scented and the other unscented, in an open field. Only males injected with naloxone during training failed to manifest a conditioned ejaculatory preference. These findings suggest that activation of opioid, but not dopamine, systems during sexual interaction are necessary for conditioned ejaculatory preference in male rats. (PsycINFO Database Record (c) 2009 APA, all rights reserved). | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19824765 |
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