| Title | Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet. | | Author(s) | Reisin E, Ebenezer PJ, Liao J, Lee BS, Larroque M, Hu X, Aguilar EA, Morse SA, Francis J | | Institution | Section of Nephrology and Hypertension, Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. ereisi@lsuhsc.edu | | Source | Am J Med Sci 2009 Oct; 338(4):301-9. | | MeSH | Animals
Base Sequence
Blood Pressure
C-Reactive Protein
DNA Primers
Dietary Fats
Feeding Behavior
Fluorescent Antibody Technique
Fluorobenzenes
Gene Expression Profiling
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Insulin
Kidney Failure, Chronic
Lipids
Pyrimidines
Rats
Rats, Zucker
Reverse Transcriptase Polymerase Chain Reaction
Sulfonamides
| | Abstract | The obese Zucker rat (OZR) spontaneously develops hyperlipidemia, insulin resistance, and microalbuminuria. In this study, the initial metabolic, functional, and glomerular pathology in young OZR fed with an atherogenic diet resembles the characteristics of metabolic syndrome. Hyperlipidemia and other metabolic derangement cause early glomerular damage in OZR by 10 weeks of age, before overt diabetes is developed. Consequently, the effects of potential interventions should also be evaluated at the young age. In OZR fed with an atherogenic high-fat diet, low (5 mg/kg) and high (20 mg/kg) dosages of rosuvastatin started at 5 weeks and maintained for 10 weeks induced a significant improvement in metabolic abnormalities, blood pressure, and renal function, including microalbuminuria. The low dose of rosuvastatin significantly decreased mesangial expansion, and the high dose exerted a marked protective effect on the development of both glomerular hypertrophy and mesangial expansion. The statin also attenuated the inflammatory expression in the kidney cortex. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19826320 |
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