| Title | Mast cell stabilizing properties of antihistamines. | | Author(s) | Levi-Schaffer F, Eliashar R | | Institution | Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. | | Source | J Invest Dermatol 2009 Nov; 129(11):2549-51. | | Abstract | Histamine is a key mediator of allergic inflammation, primarily through competitive antagonism of binding to H1 receptors. In this issue, Weller and Maurer report that the H1 antagonist desloratadine possesses mast cell-stabilizing properties when challenged in an IgE-dependent or -independent fashion. Thus, desloratadine provides benefits that are independent of H1 receptor binding and based on mast cell stabilization. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19826448 |
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