Giant Cobblestone-like Papillae During Isotretinoin Therapy. Ocular immunology and inflammation [Ocul Immunol Inflamm] Journal article

Purpose: To report a case of giant cobblestone-like papillae that appeared during oral isotretinoin therapy.
Design: Case report.
Methods: A 14-year-old boy presented with bilateral eye itching for 1 week. Bilateral upper palpebral conjunctival cobblestone-like papillae, superficial punctate keratitis, and shield ulcer in the left cornea were seen. At the time, he was treated with oral isotretinoin for 6 months.
Results: Following cessation of isotretinoin, the ulcer and SPK healed, and the papillae disappeared completely after an 8-week course.
Conclusion: Giant cobblestone-like papillae and corneal shield ulcer may be considered as a probable isotretinoin-induced ocular adverse event.

Ocular immunology and inflammation [Ocul Immunol Inflamm]